The Boston Globe reports that sales of anti-aging face care products rose 12 percent last year, a nice bump for products that may or may not do anything. Does the stuff work? According to the Globe, no one knows for sure, and there are a few wrinkles in some of their claims. The FDA has placed eight dozen companies, including Chanel, Elizabeth Arden, Estee Lauder, and Revlon, on a list of manufacturers who may have “exaggerated anti aging claims.’’ The good news, according to the Globe, is that reliable studies have shown that patients using the prescription creams containing tretinoin have gotten statistically significant improvements in wrinkling and pigmentation problems, typically brown spots, when they used it for at least six months. Still, the Globe admits, the best advice for fending off aging skin is this: Stay out of the sun.